Subjects with underlying cardiovascular disease were excluded from phase 3 clinical trials. A dose response relationship for syncope is suggested based on subject incidence across all studies. Before taking dapoxetine Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. Studies with concomitant use of dapoxetine and phosphodiesterase type 5 inhibitors do not show any significant interaction with tadalafil 20 mg or sildenafil mg. Syncope characterized as loss of consciousness with bradycardia or sinus arrest observed in patients wearing Holter monitors has been reported in clinical trials and is considered medicinal product related. · Dapoxetine oral Updated 2 Feb | Selective serotonin re-uptake inhibitors Premature ejaculation Share Check interactions Drugs List Therapeutic Indications Dosage Contraindications Precautions and Warnings Pregnancy and Lactation Side Effects Monograph Drugs List dapoxetine 30mg tablets dapoxetine 60mg tablets PRILIGY . DrugBank Accession Number. DB Background. Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. This medication is used to treat premature ejaculation. It increases time to ejaculate, and thus reduces the stress you face over how fast you ejaculate and may improve your satisfaction during sexual intercourse.