The effects may be increased because of slower removal of the medicine from the body. Vardenafil usually works for 4 to 5 hours. Medicines that block an enzyme called CYP3A4. If you take too much sildenafil or take it together with these medicines, the chance for side effects will be higher. Avanafil Stendra. May make this condition worse.Sildenafil oral tablet is used to treat erectile dysfunction (ED). It’s also used to treat pulmonary arterial hypertension (PAH). What is sildenafil? Sildenafil is a . Viagra (sildenafil) is a prescription drug that’s used to treat erectile dysfunction (ED). The drug comes as a tablet you’ll take by swallowing. It’s usually taken . Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes .