Do you take prescription medications? If the pause-squeeze technique causes pain or discomfort, you can try the stop-start technique. Do you experience premature ejaculation when you masturbate? Tadalafil and fluoxetine in premature ejaculation: prospective, randomized, double-blind, placebo-controlled study. Sadeghi-Nejad H, Seftel A. Premature ejaculation associated with citalopram withdrawal.Premature ejaculation (PE) is a prevalent male sexual dysfunction. Current standard treatment regimens include behavioural therapies, topical anaesthetics, dapoxetine and . [88] Abu El-Hamd M, Abdelhamed A. Comparison of the clinical efficacy and safety of the on-demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with . Dapoxetine is currently the oral drug of choice for on-demand treatment of PE. Keywords: Dapoxetine, premature ejaculation (PE), selective serotonin reuptake inhibitor (SSRI) .