The mechanism of action for ED pills is simple: They inhibit the PDE5 enzyme which regulates the signals responsible for the smooth muscle tissue. Female sexual dysfunction can be due to an inability to reach orgasm, painful intercourse , or lower sexual desire libido. They boost sexual performance in males by improving blood flow to the penis but do not affect libido. The most common symptoms of erectile dysfunction include difficulty achieving or maintaining an erection and reduced sexual desire. Does Viagra Work for Women? Viagra and similar drugs treat erectile dysfunction ED.There are two prescription drugs on the market that have been approved by the Food and Drug Administration (FDA) to specifically address HSDD. They are available only for . Two Medicines The drugs the FDA has approved for HSDD are: Flibanserin (Addyi): It’s a pill you take every evening. Bremelanotide (Vyleesi): It’s a shot you give yourself in the . Given the success of drugs to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis) and vardenafil (Levitra, Staxyn), drug companies have sought a similar drug for .