Medicines that block an enzyme called CYP3A4. It might work longer if you have mild to moderate erectile dysfunction. You can take this medicine with or without food 30 minutes before sex, depending on the dose. If you are taking sildenafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire. Other uses for this medicine This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.Sildenafil (Viagra). Tadalafil (Cialis). Vardenafil. These medicines are called PDE5 inhibitors. They enhance the effects of a chemical the body makes that relaxes muscles . Sildenafil (Viagra brand) only works following sexual stimulation. It works within 30 to 60 minutes, but may be taken up to four hours before sexual activity. Sildenafil (Revatio . No, you should not take Viagra if you don’t have ED. Viagra is a prescription medication that can have serious side effects. And it’s approved only to treat ED, not to be used.