What alternatives can I use for erectile dysfunction? When choosing one, tell your doctor or other health care professional what your preferences are, such as cost, ease of use, how long the drug’s effects last and side effects. Combined use could lead to additional lowering of blood pressure, possibly to unsafe levels. There may be rare occurrences of priapism or painful, prolonged erections. Tadalafil will make these symptoms less severe and reduce the chance that prostate surgery will be needed. When oral medications might not be safe Check with your health care team before you take any medicine for erectile dysfunction. The safety and effectiveness of Cialis when used with other treatments for impotence has not been studied.CIALIS for Use as Needed. Creatinine clearance 30 to 50 mL/min: A starting dose of 5 mg not more than once per day is recommended, and the maximum dose is 10 mg not more than once in every 48 hours. Creatinine clearance less than 30 mL/min or on hemodialysis: The maximum dose is 5 mg not more than once in every 72 hours [see . · Cialis; Descriptions. Tadalafil is used to treat men who have erectile dysfunction (also called sexual impotence). Tadalafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where . Since Cialis is available as a generic, many insurance plans now cover it (to varying degrees). Generally, Medicare does not cover Cialis, since it’s not considered medically necessary.